A new generation of skin rejuvenation: polynucleotides

I am always looking for considered, evidence-led ways to help skin look healthier — not different, just better. One of the more interesting developments in recent years is polynucleotide therapy, a treatment designed to support skin quality from within rather than mask it from the outside.

What polynucleotides are

Polynucleotides are purified fragments derived from natural sources. Injected into the skin, they gently encourage your own repair processes and support the production of collagen and elastin — the building blocks behind firmer, more hydrated, more resilient skin.

The key difference from traditional fillers is the goal. Fillers add volume; polynucleotides work at a cellular level to help the skin rebuild and refresh itself. That is why the results tend to look subtle and natural — skin that looks like it has had a good rest, not skin that looks ‘done’.

Where it can be used

It is a versatile treatment, used to improve texture and tone across several areas, including:

• The face — particularly cheeks, jawline and the under-eye area
• The neck and décolletage
• The hands
• The scalp and hairline

It can also be used to soften the look of scarring and stretch marks, which makes it a thoughtful option for anyone wanting smoother, healthier-looking skin overall.

Why people choose it

As we get older, the skin naturally makes less collagen and elastin, which can show as dryness, fine lines and a loss of firmness. Polynucleotide therapy aims to gently counter that by supporting the skin’s natural regeneration, encouraging collagen and elastin, improving hydration and texture, and helping a brighter, more even-looking complexion.

It works gradually, with improvement building over the following weeks as the skin continues to repair. Individual results vary, and longevity differs from person to person — but when it suits you, the change tends to feel long-lasting rather than dramatic.

Caring for skin beyond the treatment

Good in-clinic work goes further when it is supported at home, so I can suggest a simple, personalised routine to help maintain hydration and resilience between sessions. The aim throughout is regeneration rather than alteration — helping your skin do more of what it already knows how to do.

If polynucleotide therapy sounds like something you would like to understand better, the right next step is a consultation, so we can look at your skin and talk honestly about whether it is a sensible fit for you.